ECTS Abstracts (2015) 1 W1.1

Decellularised tissues

Shu Barylak


The use of biologic scaffolds composed of extracellular matrix (ECM) has found widespread use in multiple body systems including the musculoskeletal system, gastrointestinal tract, lower urinary tract, CNS, and cardio-vascular system, among others. Such ECM scaffold materials are prepared by decellularization of source tissues. The mechanism by which these inductive scaffold tissues facilitate constructive tissue remodeling include recruitment of endogenous stem cells, modulation of the host innate immune response, and the temporary mechanical substrate for tissue reconstruction. The presentation will include methods of scaffold preparation, mechanisms of action, and clinical applications with a focus upon musculoskeletal repair.

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