ECTS Abstracts (2015) 1 P46

A novel approach of bone density analysis based on bone remolding

Lan Wang1, Wen Zhang1, Zongping Luo1, Yanan Wang2 & Yanyun Zhang2

1Soochow University, Suzhou, China; 2Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Supporting our organs and human features, bones gradually adapt to their optimal structure. As external loadings change the bone structure will opt for the best shape and structure to adapt to the new loadings; this is called bone functional adaptation. Bones are not necessarily always healthy and may have defects or fractures. The implantation of bone material will cause changes to the stress upon the bones, which will in turn cause changes to the internal structure optimisation. The simulation results were obtained with different implant materials. When the elastic modulus of implant material was 0.002 Mpa, the osteogenesis rate approaches to zero, which is consistent with the clinical results. When the defect exceeds threshold, it is harder to fill by its adaptability. When E=30 Mpa, the asteogenic is less than the stiffer material because the tress is less. In the same degradation period, the effect of materials with about 1000 Mpa is better than others. When the value up to 3000 Mpa, the osteogenesis rate is down because the material degradation is slower and there is no place for bone. Theory and simulation techniques were obtained for the abnormalities situations of bone. Through computer simulation, two basic problems of matching were solved: how to quantify the impact of implant materials and how to fine the suitable biodegradable materials.

Disclosure: The authors declared no competing interests.

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