Background: Vitamin D deficiency is highly prevalent in Saudi women, however not all women show a rise in parathyroid hormone (PTH) in response to low vitamin D status. The aim of this study was to examine the differences in the characteristics of vitamin D deficient women with or without a blunted PTH response.
Methods: This was a cross-sectional study conducted in the Center of Excellence for Osteoporosis Research (CEOR). A total of 381, otherwise healthy women (aged 25-45 years), with vitamin D deficiency (serum 25(OH)D<50 nmol/ L) participated in this study. Women were divided into quartiles according to PTH levels and the highest and lowest quartiles were compared with regard to different anthropometric and biochemical factors.
Results: Women in the lowest PTH quartile (n=88) were significantly younger, had smaller waist circumference (WC), lower body mass index (BMI) and lower blood pressure compared with the highest PTH quartile. They also had higher total serum calcium, and phosphate levels. There were no significant differences in serum magnesium level or in kidney function.
Conclusions: These results suggest that a rise in PTH in response to vitamin D deficiency may be determined by extent of body fat, with a rise in PTH seen in vitamin D deficient women with higher BMI. Future studies to confirm these findings and to determine other factors affecting the vitamin D PTH relationship in obese women who are at higher cardiovascular risk are indicated.
Disclosure: The authors declared no competing interests.