Background: The aim was to investigate growth rates of bones in rats in readaptation period after application of sodium glutamate (SG) and exposure to ionising radiation (IR), and finding possibility of medication with Spirulina (Sp).
Methods: The experiment involved 240 rats with body weight of 180200 g. The animals were distributed into 8 groups as follows: intact animals for the controls, animals that received per os SG in dosage of 30 mg per kg daily for 60 days, animals exposed to IR (total 4 Grey in 4 sessions), received Sp in dosage of 250 mg per kg, combined SG and IR, SG and Sp, Sp and IR, and all three agents simultaneously. The animals were withdrawn from the experiment by the 1st, the 7th, the 15th, the 30th, and the 60th day after cessation of experimental influences. The mandibles were excised and put to strength testing at bending (V.G. Koveshnikov, V.I. Luzin, 2003).
Results: Upon SG discontinue, ultimate bending strength, elasticity modulus, and fracture energy were lower than those of controls by 7.29%, 6.24% and 6.32%; after IR discontinue same values were lower by 8.32%, 9.75% and 7.86%. After combined action of SG and IR those values were lower by 12.15%, 11.94% ? 12.22% as compared with controls. Restoration of strength features also depended on influence: by the 60th day after SG discontinue significant differences from the control values were not observed, after IR discontinue some differences were still observed, and after cessation of combined action strength features did not recover. Application of Sp reduced negative effects of experimental conditions on strength of mandible. The best recovery outcome was observed in animals that received only SG and the lowest recovery outcome was yielded in rats exposed to combined action of IR radiation and SG.
Conclusions: *60-day application of SG in dosage of 30 mg per kg of body weight and exposure to IR and their combined action results in marked decrease of bone strength that expands even to readaptation period. This fact urges searching for medication and prophylactic measures for such a state. According to our findings Sp well satisfies this demand.
Disclosure: The authors declared no competing interests.