ECTS Abstracts (2015) 1 P388

Salt Osteoporosis Study, an Open Randomised Pragmatic Trial, Studying a Primary Care Structured Identification and Treatment Programme in Women Aged 65 Years or Older: Study Design and Progress

Petra J M Elders1, Thomas Merlijn1, Natasja M van Schoor2, Coen J C Netelenbos3 & Paul Lips3

1VUmc,EMGO+ Institute, dpt of General Practice and Elderly Care Medicine, Amsterdam, The Netherlands; 2VUmc,EMGO+Institute, dpt of Epidemiology and Biostatis, Amsterdam, The Netherlands; 3VUmc,EMGO+Institute, dpt of internal medicine and endocrinology, Amsterdam, The Netherlands.

The aim of the study is to examine whether structured identification and treatment of patients with a high fracture risk in primary care reduces fractures in comparison with usual care. An open randomised pragmatic trial using a stepwise approach in women aged 65 years or older in GP practises is being performed. Women having at least one clinical risk factor for osteoporosis will be assigned to the intervention or control group using individual randomisation. Only those women with an increased fracture risk according to an adapted FRAX in combination with DEXA and IVA will be offered bone sparing drugs. The subjects in the control group will undergo the same examinations as the intervention group at the end of the three year trial and will be classified in low and high fracture risk retrospectively. Primary outcome is time to first new fracture. A comparison will be made between women in the intervention and control group having a high fracture risk. So far n=22791 women from 238 GP practices have been included in the study of which n=11702 had at least one clinical risk factor for osteoporosis and were randomized. Of the n=5933 women in the intervention group, n=1570 were classified as having high fracture risk. We shall present the design and progress of the study.

Disclosure: The authors declared no competing interests. Funded by Stichting Achmea Gezondheidszorg.

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