ECTS Abstracts (2015) 1 P381

Increased Calcium Fractional Absorption from Synthetic Stable Amorphous Calcium Carbonate

Nachum Vaisman1, Galit Shaltiel2, Michal Daniely2, Oren Meiron2, Assaf Shechter2, Amir Zalcenstein2, Steven Abrams3, Eva Niv1, Yami Shapira1, Maayan Bashan1, Mira Arbiv1 & Amir Sagi4,5

1The Unit of Clinical Nutrition, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel; 2Amorphical, Ltd, Beer Sheva, Israel; 3Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine and Texas Children’s Hospital, Houston, Texas, USA; 4Department of Life Sciences, Faculty of Natural Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel; 5National Institute for Biotechnology in the Negev (NIBN), Ben-Gurion University of the Negev, Beer Sheva, Israel.

Calcium supplementation is a widely recognised strategy for realising adequate calcium intake. Recent studies revealed comparable bioavailability of all available calcium salts. Freshwater crayfish rely on amorphous calcium carbonate (ACC), a thermodynamically instable and very rare biomineralised polymorph of calcium carbonate, characterised by distinctive nanometric spherules (in contrast to the microsized crystals found in other polymorphs), as the main mineral in the exoskeleton and in their temporary storage organ, the gastrolith. Inspired by the crayfish model, we have previously shown an increase in calcium bioavailability, bone absorption and retention in rats administered with synthetic stable ACC compared with crystalline calcium carbonate (CCC). Recently, we showed ACC’s beneficial effects on bone loss prevention, bone formation and bone mechanical strength maintenance in an ovariectomy rat model. In this randomised double-blind crossover trial we compared the fractional calcium absorption (FCA) of ACC and CCC in 13 early postmenopausal women, using the dual stable isotope technique. The results of this study showed that FCA of ACC was 2 times greater than that of CCC on average. One subject who was administered with calcium capsules in a fasted state presented X4.6 increase in ACC/CCC relative FCA, suggesting that the unique nanometric amorphous nature of ACC makes it independent on gastric acidity for adequate absorption. This study further highlights the superior absorption of synthetic stable ACC over other commercially available calcium supplements, suggesting its preferable effectiveness for prevention of postmenopausal-related bone loss and as a potential treatment for calcium malabsorption-related disorders or conditions.

Disclosure: The authors declared no competing interests. This work was sponsored by Amorphical LTD.