Background: MUSIC-OS investigates the burden of gastrointestinal (GI) events in osteoporotic women in terms of the impact on healthcare resource use (HCRU), treatment (Tx) satisfaction, adherence, and quality of life. Our objective was to examine the impact of GI events on osteoporosis (OP) related HCRU in osteoporotic women at 3 and 6 months after study entry (baseline, BL).
Methods: This prospective, observational study enrolled 2,943 participants in Canada, France, Italy, the Netherlands, Sweden and the United Kingdom. Women treated for OP were asked to report their OP related resource use at BL, and 3, 6 and 12 months post-BL.HCRU was measured by number of physician visits. Multivariate regression analysis was conducted to understand the impact of GI events on subsequent OP HCRU.
Results: The mean age of women in the analysis was 69.5 years. 938 of 2,943 (31.9%) women did not report GI events at BL. Of these, 211 (22.5%) reported a GI event by 3 months post-BL. These women had significantly higher use of OP related health care resources for their OP, compared with women who had not reported a GI event by 3 months post-BL (OR 1.5, p=0.0529, 95% CI: 1.00, 2.25). These results persist at the 6 month time point. Women who did not report a GI event at BL but had reported one by 6 months post-BL (306, 32.6%) had higher odds of OP HCRU (OR 2.33, p=0.0001, 95% CI: 1.53, 3.55), and higher odds of OP primary care HCRU (OR 1.89, p=0.028, 95% CI: 1.07, 3.34), compared with those who never had a GI event.
Conclusion: 32.6% of women without prior GI events experienced a GI event by 6 months post-baseline, resulting in higher odds of OP related HCRU compared with those who didnt have a GI event.
Disclosure: Employees of Merck &Co., Inc. helped design and provided authorship to this study. This study was fully funded by Merck & Co. Inc.