ECTS Abstracts (2015) 1 P353

Individual targeted therapy of vitamin D deficiency in postmenopausal women

Vladyslav Povoroznyuk, Nataliya Balatska, Victor Muts & Nataliia Dzerovych

D.F. Chebotarev Institute of gerontology NAMS Ukraine, Kyiv, Ukraine.

Background: The aim was to assess the efficacy and safety of individual targeted vitamin D therapy in postmenopausal women with skeletal diseases (systemic osteoporosis and osteoarthritis).

Methods: Individual targeted therapy of vitamin D deficiency consists of two periods – saturation period and maintenance therapy period, during which patients take it constantly. Duration of saturation therapy is calculated by the formula: Saturation therapy duration (days) =(100 – blood 25(??)D level (ng/mL)) ? body weight (kg) /100. The therapy for saturation includes combined calcium (1000 mg of calcium and 800 IU of vitamin D) and 3000 IU of vitamin D per day. Maintenance therapy includes 2 000 IU of vitamin D per day. The study involved 70 postmenopausal women aged 46-87 years. All patients were divided into two groups: main - 50 women who took individual targeted vitamin D therapy (50 subjects, 65.1±8.8 years old, BMI 27.22±4.51 kg/m2) and control (20 subjects, 64.5±11.1 years old, BMI 26.68±4.95 kg/m2). The duration of the treatment consists of 3 months starting on the 1st Oct 2013.

Results: In 3 months after the start of the treatment there was a significant (p<0.001) increase in 25(OH)D levels in the treatment group: 35.60±8.21 nmol/L as compared with baseline levels of 25.20±9.76 nmol/l. Remarkably, the treatment was most effective in the oldest subgroup (>70 yrs.), as well as in subjects with the BMI 25-28,99 kg/m2. After the treatment, there were no changes in calcium levels.

Conclusions: The suggested individual targeted vitamin D therapy was proven to be effective in postmenopausal women. As the treatment turned out to be effective, relatively quick, and had a reasonable safety profile it may be beneficial for all vitamin D deficient postmenopausal women.

Disclosure: The authors declared no competing interests.

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