Background: Serum levels of vitamin D, FSH, and oestradiol are associated with bone health. Vitamin D has numerous biologic effects such as enhancing calcium and phosphate absorption, production of antimicrobial peptides, anti-inflammatory activities, and development of regulatory T-cells. Insufficiency and deficiency of vitamin D has been linked to increased risk of cardiovascular diseases, infectious diseases, muscle-skeletal diseases, and cancer. The aim of this study was to determine the relationship between vitamin D insufficiency and the 10-year fracture risk compared with that of abnormal serum FSH or oestradiol levels in postmenopausal women in Taiwan.
Methods: Serum vitamin D3 [25(OH)D3], FSH, and oestradiol levels of 610 postmenopausal women were measured. These women were recruited from August 2010 to October 2013 when they visited the menopause clinic. Only those without major surgery or chronic diseases were included. The following parameters were also obtained: blood pressure, pulse rate, body temperature, body weight, body height hot flush, sweating, sleep disturbance, headache, previous fracture, living habits, alcohol consumption, and smoking.
Results: Six hundred and ten Taiwanese women in postmenopausal status with mean age 54.8 and mean years from menopause of 5 years were collected from Aug. 2010 to Oct. 2013. Those serum FSH were all higher than 30 unit/ml and oestradiol were low as all lower than 30 pg/ml. There were 515 women (84%) whose serum level of vitamin D was less than 30 ng/ml. Twenty-seven postmenopausal women had higher major fracture risk, which was counted by FRAX and higher than 10% and 35 postmenopausal women had higher hip fracture risk which was larger than 3% counted by FRAX without BMD data. The correlations between fracture risk and serum Vit D or FSH or oestradiol were calculated separately by Pearson analysis.
Conclusions: High serum FSH levels were found to have a higher correlation than vitamin D insufficiency with 10-year fracture risk in postmenopausal women in Taiwan.
Disclosure: The authors declared no competing interests. This work was supported: Grants: CMRPG891191-3 and CMRPG891171-3.