Type 1 diabetes mellitus (T1DM) is associated with increased risk of hip fracture. We aim to analyse the material properties by microindentation in women with T1DM and healthy controls as well as their correlation with BMD. Cross-sectional study including 19 well-controlled (by HbA1c) T1DM premenopausal women and 21 healthy women controls matched for age and Body Mass Index (BMI). Bone microindentation (Osteoprobe, Active Life, Santa Barbara, CA, USA), bone mineral density (DXA) and levels of 25 OH vitamin D, calcium, phosphate and iPTH were measured. In the T1DM group, glycated haemoglobin, number of hypoglycaemias, chronic complications, and presence of metabolic syndrome (MetS) according to NCEP-ATPIII criteria were analysed. Bone microindentation on the midtibia, after local anaesthesia, measured Bone Material Strength index (BMSi) as previously described (Bridges 2012). Local ERB approved the protocol and informed consent was obtained. Age (34.5+6.5 vs. 38.4+9.9), BMI, 25 OHD, iPTH, calcium and phosphate levels were similar between groups. No significant differences (mean + SD) were observed between T1DM patients and controls in BMSi (79.2±11.2 vs. 80.3±7.1) or BMD at lumbar spine (1.032±0.078 vs. 1.008±0.128) total femur (0.918±0.098 vs. 0.857±0.110) or femoral neck (0.817±0.098 vs. 0.789±0.129). In 5 patients with T1DM and microangiopathy compared with patients without, a trend towards lower BMS was observed (73.4±13.0 Vs. 80.9±10.1), although this difference was not statistically significant. Moreover, a tendency to lower BMS with increasing number of MetS criteria was seen. In conclusion, premenopausal women with well-controlled T1DM have bone tissue properties comparable to controls. There is a trend towards poorer bone mechanical properties in patients with T1DM and microangiopathy or MetS, suggest that worse control of disease may lead to worse bone quality.
Disclosure: ADP is advisor of Active Life Scientific. Supported in part by RETICEF, Instituto Carlos III, Spanish Ministry of Economy and Competitivity.