Background: The aim of this study was to evaluate the normative data of lean mass in the healthy Ukrainian women.
Methods: 301 women aged 20-87 years (mean age 57.6±0.9 yrs) were examined. The women were divided into the following age-dependent groups: 20-29 yrs (n=25), 30-39 yrs (n=27), 40-49 yrs (n=22), 50-59 yrs (n=62), 60-69 yrs (n=91), 70-79 yrs (n=59), 80-87 yrs (n=15). The lean and fat masses, bone mineral density (BMD) were measured by the DXA method (Prodigy, GEHC Lunar, Madison, WI, USA). Appendicular skeletal mass (ASM) was measured at all the four limbs with DXA. Weve also calculated the appendicular skeletal mass index (ASMI) according to the formula: ASM/height (kg/m2). Low muscle mass values conform to the following definitions: European guidelines (ASMI <5.5 kg/m2) [Cruz-Jentoft A.J. et al., 2010], less than 20% of sex-specific normal population and two SD below the mean of the young adult Ukrainian females (20-39 yrs).
Results: We observed a significant decrease of ASM with age (20-29 yrs 16.5±0.4 kg, 30-39 yrs 16.4±0.3 kg, 40-49 yrs 17.0±0.5 kg, 50-59 yrs 16.9±0.3 kg; 60-69 yrs 16.5±0.2; 70-79 yrs 15.8±0.3; 80-87 yrs 15.3±0.3; F=2.7; p=0.01). The ASMI values corresponding to a cutoff of low muscle mass by the definitions used were as follows: <5.5 kg/m2 (European guidelines), <5.7 kg/m2 (<20th percentile of sex specific population), <4.8 kg/m2 (two SD below the mean of young Ukrainian females aged 20-39 yrs). The prevalence of low muscle mass in women aged 65 yrs and older based on the above three criteria was 12%, 16% and 1.7%, respectively. ASM was positively correlated with the total fat mass (r=0.20, p=0.0006) and BMD at all sites (BMD of spine (r=0.22, p=0.0002), BMD of femoral neck (r=0.29, p<0.0001)).
Conclusion: Peak muscle mass among the Ukrainian women is achieved in the fifth decade. Appendicular skeletal mass was positively correlated with total fat mass and BMD at all sites.
Disclosure: The authors declared no competing interests.