ECTS Abstracts (2015) 1 P262

Association among Sarcopenia and Sarcodynapenia with Osteoporosis in Outpatient Elderly Men and Women

Alberto Frisoli, Fabiola Martim, Borges Jairo & Carvalho Antonio Carlos

Federal University of Sao Paulo, Sao Paulo, Brazil.

Background: Sarcopenia and weakness (dynapenia) are associated with disability and falls. Osteoporosis (OP) is associated with fractures and disability. However, there are few studies about the interactions among muscle mass, strength and bone mineral density (BMD). Our aim was to evaluate the association among sarcopenia and sarcodynapenia with osteoporosis among elderly women and men.

Methods: Cross-sectional analysis of Longitudinal study of Sarcopenia and Osteoporosis in Heart Failure Older adults outpatients. Exclusion criteria: dementia, cancer, neurodegenerative diseases, assistant advises. All patients were undergone by DXA analysis: lumbar spine (LS), femoral neck (FN), total femur (TF) and distal radio(DR).Osteoporosis was diagnosed by WHO criteria. Sarcopenia was diagnosed by appendicular muscle mass/Height 2 <5.45 kg/m2 women and <7.27Kg/m2 for men. Sarcodynapenia was considered if sarcopenia was present plus weakness (grip strength <16kgf women and 26 Kgf men).

Results: 122 elderly women (n=70) and men (n=55) were randomised, mean age 80.2 (7,0) and 79,1(6,5) years old, respectively. Osteoporosis was present in 64.1% of women and 33.3% of men. Sarcopenia occurred in 24.3% women and 48.1% of men, while, sarcodynapenia was diagnosed in 16.9% women and 22.8% of men. Among women sarcopenia and sarcodynapenia were significant more prevalent in patients with osteoporosis of FN (36.8%; p=.20 and 36.8%; p=.003, respectively) and TF (50%; p=.05 and 50%;p=0.01 respectively). However, among men, sarcopenia occurred in 100% of men with osteoporosis at LS(p=.10), TF(p=<.001), FN (p=.009) and 87.5% of RD(p=.10) and Sarcodynapenia occurred at DR(75%, p=.001), FN 66.7%,p=.005), TF (60%p=.09) and LS(66.7%p=.15). In logistic regression analysis for osteoporosis at any site, adjusted for age, sarcopenia presented OR: 31.94(3.59-283.60;0.002) and sarcodynapenia OR:16.01(2.79-91.58;0.002) among men however, among women, sarcopenia OR:1.55(0.45-5.30) and sarcodynapenia 2.03(0.048-8.55), did not present significant association.

Conclusions: Our data suggest that there are strong interactions among muscle mass and muscle strength with osteoporosis among elderly men than elderly women, independently, of age. Implications: future studies are necessary to evaluate if the treatment of sarcopenia or sarcodynapenia will interfere in osteoporosis.

Disclosure: The authors declared no competing interests.

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