ECTS Abstracts (2015) 1 P181

IL-17 Augments Osteoblast Differentiation and Bone Regeneration

Hyo Jeong Kim & Youngkyun Lee


School of Dentistry, Kyungpook National University, Daegu, Republic of Korea.


The interleukin-17 (IL-17) is a pro-inflammatory cytokine that are involved in the immune response of tissues but also play a role in bone metabolism. It was previously shown that IL-17 accelerated osteogenic differentiation of human mesenchymal stem cells while inhibited osteoblast differentiation and bone regeneration in rats. To delineate the apparent discrepancy, we evaluated the effect of IL-17 on osteogenesis in mice both in vitro and in vivo. When mouse calvarial osteoblast precursor cells were cultured for in osteogenic medium in the presence of IL-17, the alkaline phosphatase activity and the expression of alkaline phosphatase, osteocalcin, and osterix were significantly enhanced. Moreover, IL-17 significantly accelerated bone regeneration in mouse calvarial defect model. Interestingly, the expression profile of mouse osteoblast IL-17 receptor genes was similar to that of human mesenchymal stem cells, while contradicted with that of rat cells. Our results suggest a species or cell type-specific role for IL-17 in bone formation.

Disclosure: The authors declared no competing interests. This work was supported by grants from the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, and Future Planning.

Article tools

My recent searches

No recent searches.

My recently viewed abstracts