ECTS Abstracts (2015) 1 CABSOP4.5

Prevalence Of Muscle and Bone Deficits In Survivors Of Childhood Acute Lymphoblastic Leukemia: Preliminary Results Of The PETALE Study

Louis-Nicolas Veilleux, Frank Rauch, Maja Krajinovic, Caroline Laverdière, Daniel Sinnett & Nathalie Alos


Sainte-Justine Univerity Hospital Center, Montréal, Québec, Canada.


Overall cure rates for childhood acute lymphoblastic leukemia (ALL) have improved allowing the cure of over 85% of patients. At least 70% of survivors of childhood ALL cancers have substantial morbidities as a result of their disease and/or their treatment. The goal of this study was to assess the proportion of ALL long term survivors with muscle function deficit and bone health deficits.

Patients: 153 long-term ALL survivors were part of this study (62% were females; mean age at recruitment [SD]: 22.3 years [6.7]; mean age at diagnosis [SD]: 5.6 years [4.2]; 57% of patients were classified as high risk at diagnosis; average treatment duration [SD]: 26 months [4.7].

Method/Results: Mechanographic results of the multiple one-legged hopping test and the single two-legged jump test showed a higher than normal prevalence of muscle force deficit (Lower than -2SD; expected 2%; observed 12%) and a higher than normal prevalence of muscle power deficit (expected 2%; observed 17%) compared to age- and sex-specific reference range, respectively. pQCT data indicated that muscle size and density were normal. 10% of ALL survivors had bone CSA under 2 SDs relative to age- and sex-specific reference data whereas this proportion was of 7% for bone mineral content. As it would be expected, BMD lower than 2 SDs was found in 2% of the ALL survivor population.

Conclusions: A higher than normal prevalence of muscle function deficit (12-17%) and of bone size/mass deficits (7-10%) in ALL survivors was observed in this study which suggest that musculoskeletal health assessment should be part of the long-term follow-up of childhood ALL survivors.

Disclosure: This research was funded by the Canadian Institutes of Health Research (CIHR; grant number TCF-201106)

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