ECTS Abstracts (2015) 1 CABS1.1

Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone

Anjali P Kusumbe, Saravana K Ramasamy & Ralf H Adams

Muenster, Germany.

The mammalian skeletal system harbours a hierarchical system of mesenchymal stem cells, osteoprogenitors, and osteoblasts sustaining lifelong bone formation. Osteogenesis is indispensable for the homeostatic renewal of bone as well as regenerative fracture healing, but these processes frequently decline in ageing organisms leading to loss of bone mass and increased fracture incidence. There is evidence indicating that the growth of blood vessels in bone and osteogenesis are coupled, but relatively little is known about the underlying cellular and molecular mechanisms. Here, we identify a new capillary subtype in the murine skeletal system with distinct morphological, molecular, and functional properties. These vessels are found in specific locations, mediate growth of the bone vasculature, generate distinct metabolic and molecular microenvironments, maintain perivascular osteoprogenitors, and couple angiogenesis to osteogenesis. The abundance of these vessels and associated osteoprogenitors was strongly reduced in bone from aged animals, which was pharmacologically reversible to restore bone mass.

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