Tumour-induced osteomalacia (TIO) is a rare paraneoplastic process, characterised by poorly-healing fragility fractures and proximal myopathy. Inappropriately elevated levels of FGF-23 secreted from an occult mesenchymal tumour, lead to renal phosphate wasting, hypophsophataemia, decreased 1,25-vitamin D levels and subsequent fractures. Treatment is centred on localisation and removal of the causative tumour, which often achieves symptomatic and biochemical resolution. We report a case of a 47-year-old man with tumour-induced osteomalacia (TIO) from a benign tumour in the gluteus minimus muscle. Our case highlights the importance of measuring and acting upon serum phosphate in patients with fragility fractures, proximal myopathy and/or bone pain.
Disclosure: The authors declared no competing interests.