ECTS Abstracts (2015) 1 P436

Surgical Methods in Mouse Tooth Autotransplantation Research

Petra Langova1,2, Jan Stembirek1,3, Martina Pokorna1,4, Michal Navratil1,4, Eva Matalova1,5 & Marcela Buchtova1,6


1Institute of Animal Physiology and Genetics, Brno, Czech Republic; 2Department of Stomatology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; 3Department of Maxillofacial Surgery, University Hospital Ostrava, Ostrava, Czech Republic; 4Clinic of Stomatology, St. Anne’s Faculty Hospital, Brno, Czech Republic; 5Department of Physiology, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic; 6Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic.


Autotransplantation of teeth is one of the possibilities to substitute the missing teeth in the dental arch. In comparison with prosthetic dentistry and implantology, autogenous transplantation is the most natural way of tooth replacement. Although success and advantages are prevailing, there are some complications like ankylosis or inflammation, which have to be solved. To understand regenerative processes after autotransplantations, several animal models and histological/molecular methods have been established. We review recent achievements in autotransplantation techniques with using animal models and the evaluation of advantages and disadvantages of their using as showed also in our experiments. The most common laboratory animals used in autotransplantation research are mice and rats. Despite the monophyodont dentition and reduced dental formula together with hypsodont incisors and toothless diastema, numerous findings can be successfully extrapolated from rodents to humans. Various parameters of successful autotransplantation such as periodontal tissue regeneration, reinnervation or revascularisation have already been proved in the mouse. The autotransplantation of teeth currently has a firm place in the field of dentistry because of preserving the physiological properties of teeth, periodontal and alveolar bone.

Disclosure: The authors declared no competing interests. This work was supported by the Ministry of Health of the Czech Republic (grant NT 11420-6/2010), the Grant Agency of the Czech Republic (14-29273P) and institutional support (RVO:67985904).

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