ECTS Abstracts (2015) 1 P314

The Association between Metabolic Syndrome, Bone Mineral Density, Hip Bone Geometry and Fracture Risk: the Rotterdam Study

Taulant Muka1, Katerina Trajanoska1,2, Jessica Kiefte-de Jong1, Ling Oei2,4, André Uitterlinden2,3, Albert Hofman1, Abbas Dehghan1,3, Carola Zillikens2,3, Oscar Franco1,3 & Fernando Rivadeneira2,3


1Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands, Rotterdam, The Netherlands; 2Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands, Rotterdam, The Netherlands; 3Netherlands Consortium for Healthy Ageing, Netherlands Genomics Inititiative, The Hague, The Netherlands; 4Department of Internal Medicine, IJsselland Hospital, Capelle aan den Ijssel, The Netherlands.


The association between metabolic syndrome (MS) and bone health remains unclear. We aimed to study the association between MS and hip bone geometry (HBG), femoral neck bone mineral density (FN-BMD), and the risk of osteoporosis and incident fractures. Data of 2040 women and 1510 men participants in the third visit (1997-1999) of the Rotterdam Study (RSI-3), a prospective population based cohort, were available (mean follow-up 6.7 years). MS was defined according to the recent harmonised definition. HBG parameters were measured at the third round visit whereas FN-BMD was assessed at the third round and 5 years later. Incident fractures were identified from medical registry data. After correcting for age, body mass index (BMI), lifestyle factors and medication use, individuals with MS had lower bone width (β=-0.054, P=0.003), lower cortical buckling ratio (β=-0.81, P=0.003) and lower odds of having osteoporosis (odds ratio=0.56, P=0.007) in women but not in men. Similarly, MS was associated with higher FN-BMD only in women (β=0.028, P=0.001). In the analyses of MS components, the glucose component (unrelated to diabetes status) was positively associated with FN-BMD in both genders (β=0.016, P=0.01 for women and β=0.022, P=0.004 for men). In men, waist circumference was inversely associated with FN-BMD (β=-0.03, P=0.004). No association was observed with fracture risk in either sex. In conclusion, women with MS have higher FN-BMD independent of BMI. The glucose component of MS was associated with high FN-BMD in both genders, highlighting the need to preserve glycaemic control to prevent skeletal complications.

Disclosure: The authors declared no competing interests.